Sun effects on skin reveal eczema therapy clues

Monday 19th June 2017

Exposure to sunlight releases a compound from the skin that can alleviate symptoms of eczema.

The molecule - called nitric oxide - works by dampening inflammation, which causes the itchy skin lesions associated with the condition.

Scientists say their findings pave the way for new therapies that mimic the effects of the sun's rays.

These could eventually help patients avoid light therapy, which can have damaging side effects on the skin, including raising cancer risk.

Tests on healthy volunteers found that exposing a small patch of skin to UV light triggers nitric oxide to be released into the blood stream.

Further lab studies found that the chemical activates specialised immune cells called regulatory T cells, which act to dampen ongoing inflammation.

"Our findings suggest that nitric oxide has powerful anti-inflammatory properties and could offer an alternative drug target for people with eczema."  Dr Anne Astier, MRC, Centre for Inflammation Research, University of Edinburgh

In patients with eczema, the number of these cells in their blood following light therapy directly correlates with disease improvement, the University of Edinburgh team found.

Researchers say their findings could lead to new therapies for eczema, which affects around one in five children and one in twenty adults in the UK.

People with severe eczema are often prescribed tanning lamps to help manage their symptoms, but these can cause skin burning, accelerated aging and increased risk of cancer.

The study is published in the Journal of Allergy and Clinical Immunology.

"It is clear that the health benefits of sunlight stretch far beyond vitamin D and we are starting to fill in these blank spaces." Professor Richard Weller, Senior Lecturer in Dermatology, University of Edinburgh

Source: The University of Edinburgh